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QuickView for Interferon beta-1b (compound)
DrugBank
Identification
| Name: | interferon beta-1b |
|---|---|
| Name (isomeric): | DB00068 |
| Drug Type: | biotech |
| Synonyms: |
IFN-beta; Fibroblast interferon; Interferon beta precursor
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| Brand: | Betaseron (Chiron Corp), Betaseron |
| Category: | Immunomodulatory Agents, Antiviral Agents |
| CAS number: | 145155-23-3 |
Pharmacology
| Indication: | Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks. |
|---|---|
| Pharmacology: |
Interferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Type I interferons also induce the synth...
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| Mechanism of Action: |
Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and ...
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| Clearance: | 9.4 – 28.9 mL/min•kg-1 [patients with diseases other than MS receiving single intravenous doses up to 2.0 mg] |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
